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It is used medically as an appetite suppressant for short term use, as an adjunct to exercise and reducing calorie intake. Phentermine may produce cardiovascular, gastrointestinal, and CNS side effects; rare cases of pulmonary hypertension and cardiac valvular disease have been reported. It should not be used by people who have a history of drug abuse , have cardiovascular disease , hyperthyroidism , glaucoma , or are pregnant , planning to become pregnant, or breast-feeding. It should not be taken by anyone taking a monoamine oxidase inhibitor. Drinking alcohol while using phentermine may cause adverse effects. It was first introduced in , and became part of the drug combination fen-phen that was withdrawn from the market in due to the fenfluramine component damaging people's heart valves. Different formulations of phentermine as a single agent are available under various brand names, in many countries. Phentermine is used for a short period of time to promote weight loss, if exercise and calorie reduction are not sufficient, and in addition to exercise and calorie reduction. Phentermine is approved for up to 12 weeks of use and most weight loss occurs in the first weeks.

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