What are the withdrawal symptoms of tramadol

what are the withdrawal symptoms of tramadol

Study record managers: Opioid withdrawal symptoms are a major contributing factor for why opioid treatment programs often fail. Individuals with severe opioid withdrawal symptoms may experience shaking, muscle and bone pain, nausea, depression, anxiety, and drug craving. Tramadol is a medication that is currently used to treat moderate to severe pain in individuals with cancer, joint pain, or pain resulting from surgery. Withdrawal symptoms of its pharmacological profile, tramadol may also be useful in treating opioid withdrawal.

Further research is needed to confirm the benefits of tramadol for opioid addicts. The purpose of this study is to evaluate the effectiveness of tramadol at reducing opioid withdrawal symptoms in opioid-dependent individuals. This 6-week inpatient study will enroll opioid-dependent individuals. Participants will be required to reside at the research clinic for the entire study. All participants will receive morphine maintenance treatment on a daily adderall side effects alcohol. Twice a week participants will take part in experimental challenge sessions in which they will be randomly assigned to receive varying doses of tramadol, naloxone, morphine, or placebo.

These sessions will assess the ability of tramadol to suppress opioid withdrawal symptoms. Participants will complete performance tasks to measure psychomotor and cognitive functioning. Heart rate and blood pressure will be monitored throughout the experimental sessions. A specialized camera will also be used to assess pupillary response of the eyes.

Questionnaires and self-reports tramadol be completed to assess medication effects and withdrawal symptoms. Following the end of the study, all participants will be offered outpatient drug abuse treatment. Study Type: Randomized Intervention Model: Crossover Assignment Masking: Double Primary Purpose: Treatment Official Title: February Actual Primary Adderall makes adhd worse Date: December Actual Study Completion Date: Tramadol U.

Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the "tramadol" provided below. For general information, Learn About Ambien lower blood pressure and potassium levels Studies. Ages Eligible for Study: All Accepts The withdrawal Volunteers: No Criteria Inclusion Criteria:.

Hide glossary Glossary Study record managers: Search for terms x. Save this study. Warning You have reached the maximum number of saved studies Tramadol tramadol Reduce Opioid Withdrawal Tramadol The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

Listing a study does not mean it has been evaluated by the U. Federal Government. Read our disclaimer for details. NCT Recruitment Status: Completed First Posted: September 2, Last Update Posted: January 12, Study Description. Individuals with opioid addiction often experience serious withdrawal symptoms that may make relapse unavoidable. Tramadol, a medication that is currently used to treat pain caused by chronic conditions such as cancer or joint pain, may also be effective at reducing opioid withdrawal symptoms.

This study will evaluate the effectiveness of tramadol at of what are symptoms the tramadol withdrawal withdrawal symptoms in individuals addicted to opioid drugs. Drug Information available for: FDA Resources. Arms and Interventions. Primary Outcome Measures: Opioid withdrawal symptoms measured by Visual Analog Scale during the experimental sessions Opioid agonist effects measured by Visual Analog Scale during the experimental sessions Physiological effects measured by pulse oximeter, symptoms pressure, heart rate, tramadol pupillary camera during the experimental sessions.

Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. No Criteria. Inclusion Criteria: Meets DSM-IV diagnostic criteria for opioid dependence Is in good physical health Qualifies for treatment with opioid agonist therapy e. Evidence of significant medical illness e. Tramadol and Locations.

Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this what are by its ClinicalTrials. Principal Investigator: Eric C. More Information. Responsible Party: January 12, Last Verified: Opiate Addiction Opiate Dependence. National Library of Medicine U.

National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the "what are the" of the study sponsor and investigators. Recruitment Status: September 2, Last Update Posted: Opioid-Related Disorders. Tramadol Drug: Naloxone Drug: Phase 2. Study Type:. Actual Enrollment:. Withdrawal Suppression Efficacy of Tramadol. Study Start Date:. Actual Primary Completion Date:. Actual Study Completion Date:.

Accepts Healthy Volunteers: Baltimore, Maryland, United States, Johns Hopkins University.

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