Valium iv dilution sterile water temperature

Send the page " " to a friend, relative, colleague or yourself. We do not record any personal information entered above. As with other benzodiazepines, diazepam should be used with caution in patients with pulmonary disease.

Valium iv dilution sterile water temperature

For a full list of excipients, see section 6. Pharmaceutical form Solution for Injection. Clear, colourless to pale yellow liquid. In severe anxiety or acute muscle spasm, diazepam 10mg may be given intravenously or intramuscularly and repeated after 4 hours. In status epilepticus or epileptic convulsions, 0. The dose can be repeated if necessary after 30 to 60 minutes. Once the patient is controlled, recurrence of seizures may be prevented by a slow infusion maximum total dose 3mg per kg over 24 hours.

In minor surgical procedures and dentistry, 0. Elderly or debilitated patients should be given not more than half of the usual dose. Dosage reduction may also be required in patients with liver or kidney dysfunction. In status epilepticus, epileptic or febrile convulsions: Sedation or muscle relaxation: Not recommended; dosage has not been established and Diazepam Injection contains benzyl alcohol which should be avoided in injections to neonates.

In order to reduce the likelihood of adverse effects during intravenous administration the injection should valium iv dilution sterile water temperature given slowly 1. It is advisable to keep the patient supine for at least an hour after administration. Except in emergencies, a second person should always be present during intravenous use and facilities for resuscitation should always be valium iv dilution sterile water temperature. It is recommended that patients should remain under medical supervision valium iv dilution sterile water temperature at least one hour has elapsed from the time of injection.

They should always be accompanied home by a responsible adult, with a warning not to drive valium operate machinery for 24 hours. Intravenous injection may be associated with local reactions and thrombophlebitis and venous thrombosis may occur. In order to minimise the likelihood of these effects, intravenous injections of diazepam should be given into a large vein of the antecubital fossa.

Where continuous intravenous infusion is necessary it is suggested that 2ml Diazepam Injection is mixed with at least ml of infusion fluid such as Sodium Chloride Injection or Dextrose Injection and that such solutions should be used immediately. There is evidence that diazepam is adsorbed onto plastic infusion bags and giving valium iv dilution sterile water temperature. It is therefore recommended valium iv dilution sterile water temperature glass bottles should be used for the administration of diazepam by intravenous infusion.

Diazepam Injection should not be used for the primary treatment of psychotic illness. In common with other benzodiazepines the use of diazepam may be associated with amnesia and Diazepam Injection should not be used in cases of loss or bereavement as psychological adjustment may be inhibited. Diazepam may enhance the effects of other CNS depressants; their concurrent use should be avoided. Elderly and temperature patients are more prone to the CNS effects of benzodiazepines and, therefore, lower doses are required "valium iv dilution sterile water temperature" quitting adderall with wellbutrin 4.

Benzodiazepines should be used with caution in the elderly as long term use is associated with an increased risk of developing dementia. Dependence and dilution sterile water symptoms. The dependence potential of diazepam increases with dose and duration of treatment and is greater in patients with a history of alcohol or drug abuse see 4. It is low when limited to short term changing from clonazepam to lorazepam. Withdrawal symptoms may occur with benzodiazepines following normal use of valium iv dilution sterile water temperature doses for only valium iv dilution sterile water temperature periods and may be associated with physiological and psychological sequelae see Section 4.

This should be considered when treating patients for more than a few days; abrupt discontinuation should be avoided and the dose reduced gradually. Benzodiazepines may induce anterograde amnesia see 4. The condition adderall xr full price most often several hours after administration. To reduce the risk, where appropriate and possible, patients should be able to have an alprazolam and first trimester loss sleep of hours after administration.

Use in patients with concomitant mental illness. As with other benzodiazepinesextreme caution should be used if prescribing diazepam for patients with personality disorders. The disinhibiting effects of benzodiazepines may be manifested as the precipitation of suicide in patients who are depressed or show aggressive behaviour towards self and others.

There is a risk of benzyl alcohol poisoning with prolonged use of high-dose intravenous infusions of diazepam injection containing benzyl alcohol. Benzyl alcohol may cause what over the counter diet pill is similar to phentermine reactions and anaphylactoid reactions in infants and children up to three years old.

Must not be given to premature babies or neonates. This medicinal product contains benzoic acid and sodium benzoate which may increase the risk of jaundice in newborn babies. This medicinal product contains 0. To be taken into consideration by patients on a controlled sodium diet. This medicinal product contains Harmful for those suffering from alcoholism. To be taken into account in pregnant or breast-feeding women, children and high-risk groups such as patients with liver disease or epilepsy.

Enhanced sedation or respiratory or CNS depression with concomitant administration of diazepam. Concomitant use should be avoided. General anaesthetics and narcotic analgesics: Enhanced sedation or respiratory and cardiovascular depression. If such centrally acting depressant drugs are given parenterally water dilution valium iv temperature sterile conjunction with intravenous diazepam, severe respiratory and cardiovascular valium iv dilution sterile water temperature may occur; careful monitoring is required.

When intravenous diazepam is to be administered concurrently with a narcotic analgesic agent e. Premedication with diazepam may decrease the dose of fentanyl derivatives required for water sterile iv temperature dilution valium of anaesthesia. Agents that interfere with metabolism by hepatic enzymes isoniazid and to a lesser extent erythromycin may reduce the clearance of diazepam and potentiate its action. Known inducers of hepatic enzymes, for example, rifampicin, may increase the clearance of benzodiazepines diazepam.

Enhanced sedation or respiratory or CNS depression with concomitant administration of mirtazapine or tricyclic antidepressants. Diazepam plasma levels increased by concomitant fluvoxamine or fluoxetine. Enhanced sedaion or respiratory and cardiovascular depression. Known inducers of hepatic enzymes, for example, carbamazepine, phenobarbital and can wellbutrin cause manic episodes, may increase the clearance of benzodiazepines, however, despite enzyme stimulation, the net valium iv dilution sterile water temperature of adding these antiepileptics can be augmentation of benzodiazepine-induced sedation.

Serum phenytoin levels may rise, fall or remain unaltered. In addition, phenytoin may cause diazepam serum levels to fall. Concomitant sodium valproate may increase serum levels of diazepam, with associated drowsiness. Enhanced sedation or respiratory therapeutic index of tramadol cardiovascular depression with sedative antihistamines.

Valium iv dilution sterile water temperature hypotensive effect with concomitant administration of ACE inhibitors or beta-blockers or calcium-channel blockers or hydralazine. Enhanced sedative effect water valium temperature iv dilution sterile alpha blockers and possibly moxonidine. Increased plasma concentrations of zotepine.

Severe hypotension, collapse, respiratory depression, potentially fatal respiratory arrest and unconsciousness have been reported in a few patients on benzodiazepines and clozapine. Caution is advised when initiating clozapine therapy in patients taking benzodiazepines. Increased risk of hypotension, bradycardia and respiratory depression with concomitant administration of parenteral benzodiazepines with intramuscular olanzapine. Enhanced sedation or respiratory and cardiovascular depression with other anxiolytics.

Reduced clearance of digoxin. Enhanced hypotensive effect when benzodiazepines and diuretics are used concomitantly. Increased CNS depressant effects with baclofen and tizanidine. Diazepam metabolism is accelerated by smoking. Enhanced hypotensive effect when benzodiazepines and nitrates are used concomitantly. May reduce the clearance of diazepam and may potentiate its actions.

Enhanced CNS depressant effects of sodium oxybate with concomitant benzodiazepines. Cimetidine, omeprazole and esomeprazole have been shown to reduce the clearance of diazepam and may potentiate its actions. Diazepam metabolism is accelerated by theophylline. Sedative effects of diazepam reduced by caffeine. Sedative effects of diazepam reversed with concomitant administration of aminophylline 4.

It should not be used, especially in the first and third trimesters, unless the benefit is considered to outweigh the risk. If the product is prescribed to a woman of childbearing potential she should be warned to contact her physician regarding the discontinuance of the product if she intends to become or suspects that she is pregnant. There may be a small increase in the risk of congenital malformation, particularly oral cleft, with the use of benzodiazepines in the first trimester.

In labour, high single doses or repeated low doses have been reported to produce effects on the neonate, such as hyperbilirubinaemia, hypothermia, hypotonia, respiratory depression and poor suckling floppy infant syndrome in the neonate and irregularities in the foetal heart. Infants born to mothers who take benzodiazepines chronically during the latter stages of pregnancy may develop physical dependence and may be at some risk for developing withdrawal symptoms in the postnatal period.

A small number of children exposed in utero to benzodiazepines have shown slow development in the early years but by four years of age had developed normally. Since benzodiazepines are found in the breast milk, benzodiazepines should not be given to breast feeding mothers. This medicine can impair cognitive function and can affect a patient's ability to drive safely. This class of medicine is in the list of drugs included iv dilution temperature valium sterile water regulations under 5a of the Road of Traffic Act When prescribing this medicine, patients should be told: Blood and lymphatic system disorders: Blood dyscrasias including thrombocytopenia and agranulocytosis have been reported with diazepam.

Hypersensitivity reactions, including anaphylaxis, are rare. In susceptible patients, an unnoticed depression may become evident. Paradoxical reactions including aggression, rage, hostility, hallucinations, nightmares, disinhibition, euphoria, excitation, irritability, restlessness, increased anxiety, agitation, inappropriate behaviour and insomnia are known to occur with benzodiazepines and may be quite severe with diazepam. They are more likely to occur in children and the elderly.

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