Diazepam and renal disease

Renal disease and diazepam

The use of benzodiazepines with alcohol is not recommended. Patients with acute alcohol intoxication exhibit depressed vital signs. The central nervous system depressant and disease diazepam renal of benzodiazepines may be additive with those of alcohol, and severe respiratory depression and death may occur. Therapy with benzodiazepines should be administered cautiously in patients who might renal disease prone to acute alcohol intake.

The manufacturers consider the use of benzodiazepines to be contraindicated in patients with acute angle-closure glaucoma or untreated open-angle glaucoma. These agents do not possess anticholinergic activity but have very rarely been associated with increased intraocular pressure. Benzodiazepines have the potential to cause dependence and abuse.

However, abrupt renal disease following continual use of as few as 6 weeks at therapeutic levels has occasionally precipitated withdrawal symptoms. Addiction- prone individuals, such as those with a history of alcohol or substance abuse, should be under careful surveillance when treated with benzodiazepines. It may add klonopin for seizures in dogs treatment prudent to refrain from swollen tongue from adderall large quantities of medication to these patients.

After prolonged use or renal disease dependency is suspected, withdrawal of benzodiazepine therapy should be undertaken gradually using a dosage- tapering schedule. If withdrawal symptoms occur, temporary reinstitution of benzodiazepines may be necessary. Benzodiazepines are metabolized by the liver, diet pills with wellbutrin the metabolites diazepam and renal disease excreted in the urine.

Chlordiazepoxide, clorazepate, diazepam, flurazepam and quazepam undergo oxidative N-dealkylation to active metabolites that renal disease substantially longer-acting than the parent compound. These metabolites then undergo further biotransformation to pharmacologically inactive products before excretion by the kidney.

Agents that are converted to weakly active, short-acting, or inactive metabolites may be preferable in hepatic impairment. Lorazepam, oxazepam and temazepam are conjugated to inactive metabolites, while alprazolam, estazolam and triazolam undergo hydroxylation to weakly active or inactive metabolites. However, some patients may be susceptible at commonly used dosages, including the elderly, debilitated or severely ill patients, those receiving other CNS depressants, and those with limited ventilatory reserve, chronic pulmonary insufficiency or other respiratory disorders.

Therapy with benzodiazepines should be administered cautiously in these patients. Appropriate monitoring and individualization of dosage are particularly important, and equipment for renal disease should be immediately available if the parenteral route is used. Benzodiazepines, especially injectable formulations, should generally be avoided in patients with sleep apnea, severe respiratory insufficiency, or hypoxia.

The use of benzodiazepines in patients with seizure disorders may increase the incidence or precipitate the onset of generalized tonic-clonic seizures grand mal. Appropriate anticonvulsant medication might need to be initiated or the dosage increased. Status epilepticus may occur in patients with a history of seizures withdrawn rapidly from benzodiazepine therapy.

Following chronic administration, cessation of benzodiazepine therapy should occur gradually with incrementally reduced dosages. Patients should be advised not renal disease discontinue medication without first consulting with the physician. Benzodiazepines should not be administered by injection to patients in shock or coma. The hypnotic and hypotensive effects of these agents may be renal disease and intensified in such patients. The use of diazepam is considered by the manufacturer to be contraindicated in patients with clinical or biochemical evidence of significant liver disease.

Diazepam is primarily metabolized by the liver, and the metabolites are eliminated by the kidney. Due to the possibility of excess accumulation of metabolites and the unknown effects of such accumulation, therapy with diazepam should also be administered cautiously in patients with renal impairment. Monitoring renal function during treatment is recommended. Benzodiazepines depress the central nervous system and may cause renal disease exacerbate mental depression and cause suicidal behavior and ideation.

Episodes of mania and renal disease have also been reported in depressed patients treated with some of these agents. Therapy with benzodiazepines should be administered cautiously in patients with a history of depression or other psychiatric disorders. Patients should be monitored for any changes in mood or behavior. The plasma half-lives accutane vs other birth control pills benzodiazepines may be prolonged in obese patients, presumably due to increased distribution into fat.

Therapy with benzodiazepines should be administered cautiously in obese patients, with careful monitoring of CNS status. Longer dosing intervals may be appropriate. When dosing by weight, loading doses should be based on actual body weight, while maintenance dose should be based on ideal body weight to avoid renal disease. Paradoxical reactions, including excitability, irritability, aggressive behavior, agitation, nervousness, hostility, anxiety, sleep disturbances, nightmares and vivid dreams, have been reported with the use of benzodiazepines in psychiatric patients and pediatric patients with hyperactive aggressive disorders.

Such patients should be monitored for signs of paradoxical stimulation during therapy lexapro and qt on ecg benzodiazepines. The manufacturers do not recommend the use of benzodiazepines for the treatment of psychosis. There are drug interactions with Valium diazepam. Do not stop taking any medications without consulting your healthcare provider.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Anxiety XanaxLexaproCymbaltaalprazolamatenolollorazepamMore Muscle Spasm cyclobenzaprineSomabaclofentizanidinediazepamFlexerilMore Alcohol Withdrawal atenololdiazepamTenorminchlordiazepoxideLibriumclorazepateMore Endoscopy or Radiology Premedication diazepamhyoscyaminesimethiconeLevsinMyliconiopamidolMore By clicking Subscribe, I agree to the Drugs.

The easiest way to lookup drug information, identify pills, check interactions and generic names for lexapro up your own personal medication records. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. We comply with the HONcode standard for trustworthy health information - diazepam and renal disease here.

View all 13 references. View all 14 references. Pecknold JC "Discontinuation reactions to alprazolam in panic disorder. Prospective comparison of clorazepate and buspirone. Patterson WM "Triazolam withdrawal. Occurrence in patients with partial seizure disorders. The United States clinical experience. Howe JG "Lorazepam withdrawal seizures. View all 48 references. Liver Disease, Renal Dysfunction. American Medical Association; Pulmonary Impairment, Doctors that prescribe phentermine in arkansas, Respiratory Renal diazepam disease and. Sullivan RJ, Jr "Respiratory depression requiring ventilatory support following 0.

Donaldson D, Gibson G "System complications with intravenous diazepam. Ananth J "Abstinence syndrome from therapeutic doses alprazolam dose for tinnitus oxazepam. View all 36 references. View all 4 references. Renal Dysfunction, Liver Disease. View all 12 references. Psychosis, Hyperkinetic Syndrome of Childhood.

Adverse reaction to flurazepam. Rothschild AJ "Disinhibition, amnestic reactions, and other adverse reactions secondary to triazolam: Viscott DS "Chlordiazepoxide and hallucinations. View all 35 references. Drug Interaction Classification The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to "diazepam and" individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. Minor Minimally clinically significant. Unknown No information available. Valium Rating User Diazepam and renal disease 8.

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