What is stronger lorazepam or klonopin

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November 18, The benzodiazepines are a family of sedating medications used both for treatment of anxiety and vertigo. The purpose of this page is to review current evidence regarding the effects of benzodiazepines on vestibular function. The bottom line is that there is little experimental data, and that current dogma not well substantiated is that benzodiazepines suppress vestibular responses and also suppress compensation. Is alprazolam good for sleep beginning, lets acknowledge that benzodiazepines are addictive substances, and are a source of considerable passion on both sides of the issue regarding their utility for many purposes.

Much of this page involves opinions of the author, Dr. Hain, who is a experienced clinician who treats dizziness. What is stronger lorazepam or klonopin is important to realize that in situations like this, there will be many different opinions. Commonly prescribed benzodiazepines include diazepam Valiumlorazepam AtivanClonazepam, alprazolam Xanax and many others. These drugs are largely used to treat anxiety, but also are used to induce sleep, and a variety of other purposes largely involving suppression of the nervous system.

They generally are not toxic, in the sense that they generally do not damage organ systems, but also generally are associated with addiction and tolerance. Benzodiazepines are GABA modulators, acting centrally to suppress vestibular responses. They increase the affinity of chloride channel opening Soto et al, There are differential effects across benzodiazepines on Gaba-A receptor subtypes.

In small doses, these drugs are extremely useful. Addiction, impaired memory, increased risk of falling, and possibly impaired vestibular compensation are their main shortcomings. Lorazepam and Clonazepam are what is stronger lorazepam or klonopin particularly useful agents when treating dizziness because of their effectiveness and simple kinetics. Addiction, the biggest problem, can usually be avoided by keeping the dose to 0.

Other problems include higher incidence of car accidents risk x1. Fall risk is increased in the elderly by roughly the same proportions. Nevertheless, low doses of diazepam Valium 2 mg can be quite effective for dizziness. Clonazepam Klonopinis as effective a vestibular suppressant as lorazepam Ganaca et al, The author prefers to avoid use of alprazolam Xanax for vestibular suppression, because of the potential for a difficult withdrawal syndrome. Long acting benzodiazepines are not helpful for relief of vertigo.

There are many interesting things to consider concerning how these drugs are handled in the body. In particular, how strong are they we will call this activityhow long do they last in the blood, how long does their effect last in the brain, and how does this all change as people develop tolerance. In persons or animals that have never experienced these drugs, the following table illustrates roughly how powerful these are:. These values all change in people who are tolerant both because the drug may be eliminated more rapidly as well as because the nervous system may develop resistance to the effects of these medications.

The "activity" and timing also varies between sleepiness i. The "low dose" values above are the amounts that often control chronic dizziness, and also can generally be stopped abruptly without serious consequence such as seizure. In people older than 65, we suggest an what is stronger lorazepam or klonopin to reduce benzodiazepine prescriptions, as older people are more sensitive to these medications as well as have other sources of impaired judgement and balance that make these drugs more dangerous.

Some individuals are "habituated" to benzodiazepines, and take far more than the doses above. Our thought is that these persons should be "tapered down" on benzodiazepines, aiming for the safer "low dose" values. The taper typically takes place over stiff neck from phentermine months. We think that it is important to use prescription monitoring databases in this situation, and make it clear to patients that only a single medical provider will be controlling all benzodiazepine prescription.

This is to prevent patients from "gaming" medical providers. It is our opinion with partial confirmation in the literature that benzodiazepines decrease vestibular gain and also decrease phase. Although this is our what is stronger lorazepam or klonopin opinion, reinforced by considerable clinical experience, experimental evidence for the effect on the time constant is not strong.

Morrow and Young observed that large doses of benzodiazepines can reduce the gain what is stronger lorazepam or klonopin the VOR, almost eliminating it in large doses. This is also the author's opinion. Barmack and Pettorossi stated that diazepam suppressed the activity of "secondary vestibular neurons", lasting minutes We think that this statement is equivalent to saying that diazepam reduces VOR gain, which is certainly true.

The equivalent dose "what is stronger lorazepam or klonopin" humans would what is stronger lorazepam or klonopin 35 mg -- this is far more than nearly any human can tolerate without going to sleep. Of course, rabbits are not people, but again we would agree that diazepam, even in relatively small doses, reduces the gain of the VOR. Our impression, based on experience with patients, is that diazepam also what is stronger lorazepam or klonopin the time-constant ultram chairs for sale. Pettorossi et al suggested that diazepam enhances cerebellar inhibition of vestibular neurons, based on animal experiments.

Perhaps this is the mechanism for the effects on gain and phase, suggested above. Clinically, the DZ subjects' scores remained within the normal ranges for vestibulo-ocular phase and gain, suggesting that patients in whom drug cessation is problematic may not what is stronger lorazepam or klonopin to discontinue DZ before testing with the SHA rotational system. We disagree entirely with this report from many experiences with patients on benzodiazepines.

It may be that the "normal ranges" were too wide for these investigators. Blair and Gavin investigated the effects of intravenous diazepam on the VOR of monkeys, and reported a decrease what is stronger lorazepam or klonopin gain and increase in time constant. The time constant is related to phase see above. This fits with our clinical observations. Overall, there is remarkably little data on the effect of benzodiazepines on VOR gain and phase.

It seems certain that it suppresses gain, and we also think it is highly likely that it increases the time constant and increases clonazepam and one beer lag e. Someone should do a study. Dogma states that benzodiazepines impair vestibular compensation. There are several variants of compensation -- static and dynamic.

Static compensation has to do with restoration of the drug tramadol for ulcer pain. This happens, generally speaking, irrespective of the drug environment. Martin et al finasteride 10 mg dose that "These results suggest that even high doses of diazepam before and following UL do not result in an impairment of compensation of SN in guinea pig.

Peppard suggested that amphetamines improved compensation, but that "other drugs" had either little effect on recovery or hindered it. Ishikawa and Igarashi found no major effect on balance or nystagmus in monkeys given diazepam We find this peculiar. Diazepam did not delay vestibular compensation in the cat Bernstein et al, Overall, no substantial data appears to be present to substantiate the dogma that there is an adverse effect of benzodiazepines on compensation of vestibular responses.

Addiction to benzodiazepines, as well as diversion of prescriptions for use as "street" drugs, is an immense problem. This subject seems to attract passionate appeals against their use, presumably being driven by emotionally trying experiences with addicts. Benzodiazepines, like ethanol containing beverages, are what is stronger lorazepam or klonopin used to self-medicate anxiety, and for recreational purposes.

Benzodiazepines are rarely sources of death from overdose, by themselves. Nevertheless, when mixed with other drugs, such as alcohol or opiates, benzodiazepines can be associated with death due to respiratory arrest. Thus prescription of benzodiazepines to persons prone to take "mind altering" substances, such as opiates, is particularly dangerous. It may be that use of benzodiazepines impairs the addicts "common sense" and makes it more likely that there will be a drug overdose of alcohol or opiates.

Practically, all benzodiazepines what is stronger lorazepam or klonopin addictive in the sense that they are associated with a withdrawall syndrome after prolonged use. This is of course also true for alcohol and opiates. Addiction is not necessarily a reason to avoid using a useful drug -- but it is part of the "cost benefit" equation. It has been our experience that intelligent, high functioning individuals such as most attorneys or doctorsalmost never take benzodiazepines.

The decision as to whether or not members of society should be allowed to ingest substances such as beer, benzodiazepines, opiates or marijuana that alter their judgement, is a legal one, going on lexapro again involves setting does zolpidem make you gain weight "needle" selecting the amount to which society stronger or klonopin is what lorazepam be able to control their member's behavior.

Of course, this varies from country to country. From a medical perspective, benzodiazepines are very effective drugs to control vertigo. Medical practitioners are generally called upon to what is stronger lorazepam or klonopin whether or not there is a reasonable medical purpose to use of benzodiazepines or opiates. In as much as these drugs are used to treat subjective sensations, these decisions generally have no basis is klonopin lorazepam what stronger or objective data, and depend on "judgement" calls.

One tramadol dot drug test whether this decision is properly the province of all medical providers that can prescribe. Lader et al suggested that "The benzodiazepines are now recognized as major drugs of abuse and addiction. Other drug and non-drug therapies are available and have a superior risk benefit ratio in long-term use.

It is concluded that benzodiazepines should be reserved for short-term use--up to 4 what is stronger lorazepam or klonopin in conservative dosage. "What is stronger lorazepam or klonopin" author of what is stronger lorazepam or klonopin page, Dr. Hain, holds the taking xanax after food that medical use of benzodiazepines should generally i. There are rarely patients where doses greater than low doses seem justified - -these are generally people who have clear and objective signs of vertigo i.

When patient's refuse reasonable medical management -- for example a surgical procedure to eliminate vertigo -- in favor of benzodiazepine usage, "what is stronger lorazepam or klonopin" creates an ethical problem that is best resolved by a sensible clinician. There is no iron clad rule. Hain also feels that benzodiazepines should not be "first treatment" for dizziness, but rather should be part of a "stepped" protocol, beginning with alternatives such as anticholinergic drugs -- usually meclizine.

Individuals who are also taking other drugs that are often abused, such as opiates, are at higher risk, and prescriptions should be tramadol hcl 50 mg tablet street price limited. All of this being considered, there nevertheless are some patients who function well on low doses of benzodiazepines, and who are unable to function e.

We think that "less harm" is done by continuing treatment than stopping. Benzodiazepines are commonly used in emergency departments and medical offices to treat vertigo. We think this stronger klonopin or what is lorazepam reasonable, albeit in small what is stronger lorazepam or klonopin. By small, we mean 5mg of diazepam or lessor 1 mg of lorazepam or less. We do not think that this amount of diazepam or lorazepam should be continued for long periods of time, for acute vertigo.

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