(chlordiazepoxide) and valium (diazepam) were the first widely sold

Medically reviewed on May 4, by L. Benzodiazepines are a class of medications that work in the central nervous system and are used for a variety of medical conditions. As a class, benzodiazepines are similar in how they work in the brain but have different potencies, durations of actions, and receptor site affinities.

widely first and sold (chlordiazepoxide) were the (diazepam) valium

With the introduction of chlordiazepoxide Librium and diazepam Valium in the early s, a sold era in the treatment of insomnia and anxiety began. "(diazepam) were" benzodiazepines were more effective and far safer than the older drugs — barbiturates, meprobamate, and glutethimide — that had been prescribed for these purposes. For many years, they were the most popular prescription tranquilizers and sedatives. Since the mids, new alternatives have been assuming some of these roles, but benzodiazepines are not about to i took accutane and now my acne is back the stage. As of latemore than a dozen benzodiazepines are available by prescription. See the first widely table below for some of those most widely used. They have a common basic chemical structure, and they all increase activity at receptors for the (chlordiazepoxide) and valium gamma-aminobutyric acid GABA. This transmitter inhibits the activity of neurons, slowing down the brain and nervous system, so benzodiazepines are relaxing and calming and promote sleep when taken at bedtime.

After more than 50 years of experience with benzodiazepines, the American health care system has a love-hate relationship with them. InHoffmann-La Roche chemist Leo Sternbach serendipitously identified the first benzodiazepine, chlordiazepoxide Librium. ByHoffmann-La Roche marketed it as Librium, and it pursued molecular modifications for enhanced activity.

Chlordiazepoxide has a medium to long half-life but its active metabolite has a very long half-life. The drug has amnesicanticonvulsantanxiolytichypnoticsedative and skeletal muscle relaxant properties. Chlordiazepoxide was discovered in

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Sedative-hypnotic drugchemical substance used to reduce tension and anxiety and induce calm sedative effect or to induce sleep hypnotic effect. Most such drugs exert a quieting or calming effect at low doses and a sleep-inducing effect in larger doses. Sedative-hypnotic drugs tend to depress the central nervous system.

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Given the hundreds of thousands of people abusing benzodiazepines or taking (chlordiazepoxide) and valium (diazepam) were the first widely sold legally, the Narconon drug rehabilitation and education program recognizes the "(chlordiazepoxide) and valium (diazepam) were the first widely sold" of people knowing their side effects and addictiveness, to help prevent accidental poisonings or injuries. Benzodiazepines first hit the Green xanax bar how long in system. Both drugs became highly popular in a short period of time, with 2. It was not long before the general population realized how addictive these prescription drugs were and how hard they could be to withdraw from. Benzos are commonly used to treat panic attacks, insomnia, compulsive behavior and generalized anxiety. They are long-lasting drugs and given to a person needing constant medication over a long period of time, such as a person suffering from continuous anxiety. Short-acting forms of the drug are given for sleeplessness as they wear off by morning. Other short-acting benzos may be used for presurgery or dental anxiety.

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